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Epstein Barr virus and cancer

Epstein-Barr Virus and Cancer Clinical Cancer Researc

Epstein-Barr virus and nasopharyngeal carcinoma. Since its discovery 50 years ago, Epstein-Barr virus (EBV) has been linked to the development of cancers originating from both lymphoid and epithelial cells. Approximately 95% of the world's population sustains an asymptomatic, life-long infection with EBV. The virus persists in the memory B-cell po. Approximately 98 percent of all adults are infected with the Epstein-Barr virus. In rare cases, an infection with this virus causes cancer. Scientists have now discovered that a component of the.. There are several oncoviruses, or viruses that causes cancer: Epstein-Barr virus (EBV) is a herpes virus that's spread through saliva. EBV infection increases the risk of Burkitt lymphoma, some types of Hodgkin's and non-Hodgkin's lymphoma and stomach cancer. There is currently no vaccine for Epstein-Barr virus

HPV also has a role in causing cancers of the penis, anus, vagina, vulva, mouth and throat. Smoking, which is also linked with these cancers, may work with HPV to increase cancer risk. Other genital infections may also increase the risk that HPV will cause cancer. You can get more details in HPV and Cancer Epstein-Barr virus (EBV) is a human tumor virus and is etiologically linked to various malignancies. Certain EBV-associated diseases, such as Burkitt lymphomas and nasopharyngeal carcinomas, are endemic and exhibit biased geographic distribution worldwide Epstein Barr Virus (EBV) is one stealth virus that may potentially lead to cancer. Along with herpes, shingles, and chicken pox, EBV is part of the herpes virus family. Over 95% of adults worldwide harbor lifelong latent EBV infection and will test positive for this virus. Most children are infected as well

Not all people who become infected with EBV go on to develop cancer; but in rare instances, the virus can raise people's risk of developing nasopharyngeal cancer, Burkitt's lymphoma and certain.. Epstein-Barr virus (EBV), an established cause of lymphoma and nasopharyngeal carcinoma, has been detected in approximately 10% of gastric tumours (Young and Rickinson, 2004), leading to speculation that it may also cause gastric cancer.Previous studies relating EBV to gastric cancer have primarily been tumour-based

EBV is a very common virus - more than 9 in 10 people are infected worldwide. But, very rarely the infection will go on to cause cancer. Less than 1 in 300 UK cancer cases are caused by EBV. EBV can be linked to cancers in the UK, including: Just under half of all Hodgkin lymphoma cases. 1 in 5 cases of Burkitts lymphoma, a rare type of Non. Epstein-Barr virus (EBV) EBV is a common type of herpes virus. It is one of the most common viruses in humans, affecting more than 90% of people in the world before the age of 20. This virus causes infectious mononucleosis (mono or the kissing disease). Infection with EBV usually happens in childhood Detection of Epstein-Barr virus (EBV) in the neoplastic tissues of breast cancer cases has been reported by some authors , , , , , . The relationship between breast cancer and EBV could be of potential importance not only for better understanding of breast cancer etiology, but also for early detection, prevention of breast cancer and treatment The Epstein-Barr virus is associated with many human cancers -- including Burkitt's lymphoma, nasopharyngeal carcinoma, Hodgkin's disease and invasive breast cancer, Robertson says. The virus is. Patients with brain tumor or pancreatic cancer exhibit the poorest prognosis, while immune fitness and cellular immune exhaustion impacts their survival immensely. This work identifies differences in the immune reactivity to the common human pathogens cytomegalovirus (CMV) and Epstein-Barr virus (EBV) between patients with brain tumor in comparison to those with pancreatic cancer and healthy.

Epstein-Barr virus strain variation and cance

  1. Epstein-Barr virus (EBV)-associated gastric cancer (EBVaGC) is a common malignant tumor associated with EBV infection. The molecular classification of gastric carcinoma indicates that EBVaGC is a distinct subtype in terms of oncogenesis and molecular features. Viral proteins, Bam-HI-A rightward transcripts (BART) miRNAs, and Bam-HI A.
  2. Cancer & Epstein Barr Virus - Radio Show Archive by Medical Medium published on 2017-11-04T01:20:59Z Listen to this Medical Medium webinar to learn the undiscovered causes of cancer
  3. The Epstein-Barr virus is also linked to cancer, with some estimating that the virus contributes to around 1.5% of cancer cases around the world. The link between cancer and the Epstein-Barr virus is not new - the virus was linked to Burkitt's lymphoma as early as 1964
  4. Epstein-Barr virus (EBV) contributes to about 1.5% of all cases of human cancer worldwide, and viral genes are expressed in the malignant cells. EBV also very efficiently causes the proliferation.
  5. Download Citation | Epstein-Barr Virus and Cancer | Epstein-Barr virus is widespread in all human populations, and is usually carried as an asymptomatic persistent infection. In a small.

[Epstein-Barr virus and cancer]

  1. Symptoms include fever, sore throat, swollen lymph nodes, rash, and an enlarged spleen and liver. Epstein-Barr virus particles. More importantly, EBV can cause cancer. It is associated with cases of Hodgkin's lymphoma, Burkitt's lymphoma, and gastric and nasopharyngeal cancers. As for most viruses, people with compromised immune systems are.
  2. Request PDF | Epstein-Barr virus and cancer | EBV was the first human virus to be directly implicated in carcinogenesis. It infects >90% of the world's population. Although most humans coexist.
  3. In March 1964 The Lancet medical journal published a remarkable piece of research from three scientists called Anthony Epstein, Yvonne Barr, and Burt Achong. They had discovered the first human virus that can cause cancer, which later came to bear two of their names: Epstein-Barr virus (EBV)
  4. Abstract. It is more than 50 years since the Epstein-Barr virus (EBV), the first human tumour virus, was discovered. EBV has subsequently been found to be associated with a diverse range of.
  5. Epstein-Barr virus (EBV) 1 preferentially infects B lymphocytes through the binding of the major viral envelope glycoprotein gp350 to the CD21 receptor on the surface of B cells 2, and through.
  6. The Epstein-Barr virus (EBV) has an important and multifaceted role in liver pathology. As a member of the herpes virus family, EBV establishes a persistent infection in more than 90% of adults. Besides acute hepatitis during primary infection, many clinical syndromes of interest for the hepatologist are associated with EBV infection
  7. As the etiology and progression of breast cancer remain incompletely understood, novel routes of disease pathogenesis are important to consider. Viral pathogens have not been much explored, but recent interest has focused on Epstein-Barr virus (EBV). Studies of an association of this ubiquitous herpesvirus with breast cancer have had notably inconsistent results, marked by varying EBV presence.

Epstein-Barr Virus, the root cause of most cancers . Health (5 days ago) Epstein-Barr is responsible for mystery illnesses of every category. For some people, it creates fatigue and pain that go unnamed. For a cancer to form the body needs to have a toxin and a virus.The virus responsible is mostly EBV. Breast cancers, thyroid cancers, lung and liver and some brain are all caused by EBV The scientists hope that a way to avoid EBV infection would help prevent cancers caused by Epstein-Barr virus and save many lives. Also, since the virus is known to target the immune cells like lymphocytes, the research is also directed at finding a prevention strategy against EBV-linked cancer by modifying the immune response of the body Abstract. Epstein-Barr virus (EBV) infection is found in a subset of gastric cancers. Previous reviews have exclusively focused on EBV-encoded small RNA (EBER) positivity in gastric cancer tissues, but a comprehensive evaluation of other type of studies is lacking. We searched the PubMed database up to September, 2014, and performed a. University of New South Wales. (2012, July 31). Two viruses link to prostate cancer: High-risk human papilloma virus found with Epstein Barr virus. ScienceDaily. Retrieved August 2, 2021 from www.

Viruses | Free Full-Text | Epstein-Barr Virus (EBV

Epstein-Barr virus (EBV), as a member of the Herpesviridae family, is the first described human cancer virus and is responsible for approximately 1.8% of all human cancers, including Hodgkin lymphoma, Burkitt lymphoma, NK/T cell lymphoma, and nasopharyngeal carcinoma . However, the role of EBV in the development of other malignancies is still. Epstein-Barr virus (EBV)-positive gastric carcinoma (GC) is a histological and molecular subtype that is defined by the proliferation of GC cells infected with EBV, demonstrated by EBV-encoded small RNA (EBER)-in situ hybridization (ISH) [1, 2].EBV-positive GCs account for approximately 10% of GC cases worldwide and have a number of characteristic clinicopathological features, including. Helicobacter pylori (H. pylori) and Epstein - Barr virus (EBV) plays a significant role in aggressive gastric cancer (GC). The investigation of genes associated with these pathogens and host kinases may be essential to understand the early and dynamic progression of GC. The study aimed to demonstrate the coinfection of EBV and H. pylori in the AGS cells through morphological changes. Some virus types are associated with specific cancers and can convert normal cells into cancer cells. Examples of viruses associated with cancer are: papillomavirus-cervical cancer, hepatitis virus-liver cancer, Epstein-Barr virus-Burkitt's lymphoma. Virus-induced transformation of cells was one of the very first model systems for the study of. Background A large number of epidemiological studies have evaluated the association between Epstein-Barr virus infection and breast carcinoma risk but results have been inconsistent. Methodology Research using the polymerase chain reaction technique for detecting the Epstein-Barr virus was selected; 24 studies and 1535 cases were reviewed. Information on the study populations, sample types.

How Epstein-Barr Virus Causes Cancer American Council on

Epstein-Barr virus-associated gastric cancer: disease that

Abstract: The Epstein-Barr virus (EBV) was discovered in 1964 by Michael Anthony Epstein and Yvonne Barr, who discovered a herpesvirus-like infectious agent in a biopsy specimen from a patient with Burkitt's lymphoma. This virus belongs to the Herpesviridae family (subfamily Gammaherpesvirinae, genus Lymphocryptovirus). EBV is a ubiquitous herpesvirus that is causally associated with various. Epstein-Barr virus (EBV) is an oncogenic virus implicated in the pathogenesis of a number of human malignancies of both lymphoid and epithelial origin. Thus, a comprehensive and up-to-date analysis focused on the global burden of EBV-attributable malignancies is of significant interest. Based on published studies, we estimated the proportion of Burkitt's lymphoma (BL), Hodgkin's lymphoma.

Epstein-Barr virus is pathogenically associated with a well defined group of lymphoid and epithelial tumors in which the virus directly drives transformation of infected cells. Recent evidence however indicates that this virus may infect a subpopulation of tumor cells in patients with chronic lymphocytic leukemia (CLL) and EBV infection has been also associated with Richter transformation in a. Virusul Epstein Barr și cancerul. Infecția cu EBV poate crește riscul de apariție a unor cancere rare. Acest lucru este dat de faptul că mutațiile din celulele infectate cu EBV pot duce la modificări canceroase. Unele tipuri de cancer care sunt asociate cu EBV includ: cancerul nazofaringian

El virus Epstein Barr es uno de los siete virus que comparten la característica de inducir el cáncer en humanos. Está presente en hasta un 40% de los linfomas de Hodgkin y un 10% de los cánceres gástricos y ha sido asociado con el cáncer de nariz y garganta, el sarcoma de Kaposi y otros linfomas Abstract. Introduction: Nasopharyngeal carcinoma (NPC) is a multifactorial disease with genetic, viral, environmental and lifestyle-related risk factors. Epstein-Barr virus (EBV) can promote the oncogenic transformation of an infected cell into malignant. EBV encodes many stimulating products including Epstein-Barr virus nuclear antigen-1 (EBNA-1) which plays a key role in the regulation. Epstein-Barr virus and breast cancer: epidemiological and Molecular study on Egyptian and Iraqi women. J Egypt Natl Cancer Inst. 2012;24(3):123-31. Article Google Scholar 63. Hachana M, Amara K, Ziadi S, Romdhane E, Gacem RB, Trimeche M. Investigation of Epstein-Barr virus in breast carcinomas in Tunisia Most people may associate Epstein-Barr virus with infectious mononucleosis, but the tumor virus also has been implicated in at least five kinds of human cancer. The cancers include Burkitt's. 1. Overview of EBV as an oncogenic virus in human cancers. The Epstein-Barr virus (EBV) was the first human tumour virus to be discovered [].Also known as human herpes virus type 4 (HHV4), EBV is grouped together with other human pathogenic herpes viruses including herpes simplex virus (HSV) 1 and 2, varicella zoster virus (VZV), cytomegalovirus (CMV) and human herpes viruses (HHVs) 6, 7 and 8

Helicobacter pylori co-infection with Epstein-Barr virus and the risk of developing gastric adenocarcinoma at an early age: Observational study infectious agents and cancer July 2021 Annals of. Expression of Epstein-Barr virus latent gene products and related cellular activation and adhesion molecules in Hodgkin's disease and non-Hodgkin's lymphoma arising in patients without overt pre-existing immunodeficiency. Hum Pathol 1993;24(7):725-9. 13- Niedobitek G, Young LS. Epstein-Barr virus persistence and virus-associated tumors In this book, outstanding researchers from the US and Japan review recent progress in Epstein-Barr virus research. Most people carry EBV in memory B-cells in a latent stage. Many malignancies such as T/NK cell lymphoma, AIDS-associated B-cell lymphoma, gastric carcinoma and Hodgkin's disease hav Barr virus or EBV, as the first oncogenic human virus to be iden- tified, has been at the vanguard of these studies and even 40 years after its discovery the virus continues to fascinate and. Abstract. Herpesviruses are ubiquitous in various species, including humans, and some are causally associated with naturally occurring tumors. The Epstein-Barr virus (EBV), which was first discovered in a culture of African Burkitt's lymphoma in 1964 by Epstein and coworkers Achong and Barr as a previously unknown viral agent, is now considered to be one such oncogenic herpesvirus

Update on Epstein-Barr virus and gastric cancer (review

In this book, outstanding researchers from the US and Japan review recent progress in Epstein-Barr virus research. Most people carry EBV in memory B-cells in a latent stage. Many malignancies such as T/NK cell lymphoma, AIDS-associated B-cell lymphoma, gastric carcinoma and Hodgkin's disease have been causally linked to EBV Biorned & Pharmacother 1997;51:258-267 0 Elsevier. Paris Dossier irus and Cancer Epstein-Barr virus genes and cancer cells PJ Farrell I Cludts A Stiihler udwig Institute for Cancer Research and eportment of Medical Microbiology, Imperial College School of Medicine at St Mary, IVorfolk Place, London W2 IPG

The approach of this review is mostly to bring forward the insights of some of the potent carcinomas that are directly related to the pathogenesis of this virus, elucidating the viral proteins -: EBNA-1, EBNA-2, EBNA-LP, EBNA-3A, 3B, 3C, LMP-1, their direct association with human p53, p63, p73 & their isoforms in regulating the tumour inducing. 95% of Adults Have A Virus Linked To Breast Cancer And Autoimmune Disorder. Along with herpes, shingles, and chicken pox, Epstein-Barr virus, or EVB, is part of the herpesvirus family (HHV-4 herpes). EBV can cause mononucleosis (the kissing disease) but usually, it doesn't This will tell us more about how the virus drives lymphoma development and will help to identify new ways of targeting Epstein-Barr virus-infected cancer cells with specific drugs. The study was made possible in part with funding from the UK blood cancer charity Bloodwise, which welcomed the findings as a sign of progress in tackling EBV. Epstein Barr virus (EBV) is a very common virus that can increase the risk of nasopharyngeal cancer. Most people carry EBV and it does them no harm. This virus is linked to other cancers including Hodgkin lymphoma and Burkitt's lymphoma, which is a type of non Hodgkin lymphoma. EBV can cause genetic changes in cells that make them more likely. The Epstein-Barr virus (EBV) is a DNA lymphotropic herpesvirus and the causative agent of infectious mononucleosis. EBV is highly prevalent since it affects more than 90% of individuals worldwide and has been linked to several malignancies including PTLDs, which are one of the most common malignancies following transplantation. Among all the EBV genes, most of the recent investigations.

PDF | On Jan 1, 2002, Wing C. Chan and others published Epstein-Barr Virus and Breast Cancer | Find, read and cite all the research you need on ResearchGat Objective Plasma Epstein-Barr virus (EBV) DNA is considered a biomarker for nasopharyngeal carcinoma (NPC). However, its long-term role in NPC development is unclear. Materials and methods A total of 1363 participants seropositive for EBV VCA-IgA and EBNA1-IgA in a community-based NPC screening program in southern China were tested for plasma EBV DNA levels by real-time qPCR between 2008 and. The Epstein Barr virus (EBV) is very widespread. More than 90 percent of the world's population is infected - with very different consequences. Although the infection does not usually affect people, in some it can cause glandular fever or various types of cancer Epstein-Barr virus and breast cancer: Epidemiological and Molecular study on Egyptian and Iraqi women. By Waleed Mohamed. Epstein-Barr virus, human papillomavirus and mouse mammary tumour virus as multiple viruses in breast cancer. By Elyda Gonçalves. Download pdf Overcoming cellular senescence is strictly required for virus-driven tumors, including those associated with Epstein-Barr virus (EBV). This critical step is successfully accomplished by EBV through TERT expression and telomerase activation in infected cells. We herein review the complex interplay between EBV and TERT/telomerase in EBV-driven tumorigenesis

Special Issue Epstein-Barr Virus Infection in Cance

The first human tumor virus was discovered in 1964 by Anthony Epstein and Yvonne Barr. The identification of the Epstein Barr Virus (EBV) and the cancers it contributes to has since then been the subject of considerable scientific research. Along with herpes, shingles, and chicken pox, EBV is part of the herpes virus family. Over 90% of the. (1994) Incidence of latent infection of Epstein-Barr virus in lung CA Cancer J Clin 55: 74 - 108 & 2011 Cancer Research UK British Journal of Cancer (2011) 105(2), 320 - 326 Epstein - Barr virus microRNAs and lung cancer J Koshiol et al 326 Pegtel DM, Cosmopoulos K, Thorley-Lawson DA, van Eijndhoven MA, Simon RM, Korn EL, McShane LM.

Cancers | Free Full-Text | NF-κB Signaling Regulates

Epstein-Barr Virus: What to Know, From Mono to Cance

The study shows that a protein produced by the Epstein-Barr virus, called EBNA2, binds to multiple locations along the human genome that are associated with these seven diseases Findings of polymerase chain reaction (PCR) studies of cytomegalovirus (CMV) and Epstein-Barr virus (EBV) and breast cancer vary, making it difficult to determine whether either, both, or neither virus is causally associated with breast cancer. We investigated CMV and EBV in paired samples of breast cancer and normal breast tissue from 70 women using quantitative PCR Epstein-Barr virus glycoprotein gB and gHgL can mediate fusion and entry in trans, and heat can act as a partial surrogate for gHgL and trigger a conformational change in gB. J Virol. 2014;88(21):12193-201. Tugizov SM, Berline JW, Palefsky JM. Epstein-Barr virus infection of polarized tongue and nasopharyngeal epithelial cells Epstein-Barr virus is a ubiquitous human herpesvirus whose primary infection causes mononucleosis, Burkett's lymphoma, nasopharyngeal carcinoma, autoimmune diseases, and gastric cancer (GC). The persistent infection causes malignancies in lymph and epithelial cells. Helicobacter pylori causes gastritis in human with chronic inflammation

Epstein-Barr virus test: Procedure, results, and

Epstein-Barr virus (EBV) - Canadian Cancer Societ

Notably, breast cancers have been associated with viruses, with estimates of 15 to 20% according to the International Agency for Research on Cancer (IARC). While the best studied viral role in breast cancer are mouse mammary tumor virus-like sequences (MMTV-LS), Epstein-Barr virus (EBV) and human papillomavirus (HPV) recent recommendations. The fourth post in our Cancer and Infections series is a continuation of the Epstein-Barr virus (EBV) story.From its remarkable discovery 50 years ago, we've continued to fund research in this area that has led to pioneering new treatments for some EBV-linked cancers

The Role of Viral Proteins in Epstein-Barr Virus Induced

Epstein-Barr Virus and Cancer Annual Review of Pathology

Epstein-Barr virus (EBV), which ubiquitously infects more than 90% of the world's population, was the first human tumor virus identified to be causally associated with various lymphoid and epithelium malignancies . However, the underlying mechanism of how EBV contributes to cancer is still poorly understood Epstein Barr virus (EBV) is a common virus in the herpes virus family that affects up to 90 percent of the population before the age of 20. Not everyone will develop EBV symptoms. When they do occur, Epstein Barr virus symptoms can include: fatigue, loss of appetite, fever, sore throat, swollen glands, skin rash, and swollen liver and spleen Penn Researchers Find Epstein Barr-like Virus Infects and May Cause Cancer in Dogs. PHILADELPHIA -- More than 90 percent of humans have antibodies to the Epstein Barr virus. Best known for causing mononucleosis, or the kissing disease, the virus has also been implicated in more serious conditions, including Hodgkin's, non-Hodgkin's. Circulating Epstein-Barr virus DNA was measured in 20,174 asymptomatic participants in Hong Kong; 34 of 309 with positive results had nasopharyngeal cancer. Stage distribution and progression. The Epstein-Barr virus BART microRNAs target the pro-apoptotic protein Bim. Virology. 2011;412:392-400. CAS PubMed PubMed Central Google Scholar 62. Wang J, Zheng X, Qin Z, Wei L, Lu Y, Peng Q, et al. Epstein-Barr virus miR-BART3-3p promotes tumorigenesis by regulating the senescence pathway in gastric cancer

Epstein-Barr virus and nasopharyngeal carcinom

The Connection Between the Epstein-Barr Virus and Thyroid Health. We have talked about how the Epstein-Barr virus can affect different areas of the body, but I want to talk specifically about its effect on thyroid health. The connection between the Epstein-Barr virus and thyroid health occurs during stage three of the virus Epstein-Barr virus (EBV) is well known as the cause of infectious mononucleosis, but it is also linked to cancers such as Burkitt lymphoma, B- and T-cell lymphomas, Hodgkin lymphoma, gastric cancer, and nasopharyngeal carcinoma (NPC). The incidence of NPC varies dramatically by geographic region, ethnicity, and gender Introduction. Microbial infection causally accounts for more than 20% of malignancies worldwide ().Epstein-Barr virus (EBV) is a human gammaherpesvirus that infects approximately 95% of the global population and linked to various types of epithelial and lymphoid cancer, including nasopharyngeal carcinoma (NPC; ref. 2).Elevated EBV infection titers in serum, induced by environmental stress.

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Epstein-Barr virus and cancer: New tricks from an old dog

Symptoms. Complications. Testing. Transmission. Prevention. Epstein-Barr virus (EBV) infects most of the world's population—around 95% of adults. 1  Although infection with the virus often doesn't cause symptoms at all, it can also lead to mononucleosis, which can cause symptoms like fever and fatigue Epstein-Barr virus (EBV)-associated gastric cancer (EBVaGC) is a common malignant tumor associated with EBV infection. The molecular classification of gastric carcinoma indicates that EBVaGC is a. Gastric cancer (GC) is a deadly disease and it was the second leading cause of cancer mortality worldwide in 2018, responsible for 783 000 deaths. 1 The bacterium Helicobacter pylori and Epstein-Barr virus (EBV) still represent the majority of infectious agents causing GC. 2-5 As a human oncogenic virus, EBV has been identified in several.

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7 viruses that cause cancer MD Anderson Cancer Cente

In Epstein-Barr Virus Solution, Dr. Kines provides a groundbreaking examination of EBV and not only how it causes chronic fatigue, autoimmune disorders, and even cancer but also how recovery is possible. This book was written in hopes that it will globally change the way EBV is understood, diagnosed, and treated.The deep journey into the. Epstein-Barr Virus: Understanding Its Role in Autoimmunity and Cancer. Most of us know about Epstein-Barr Virus (EBV) as the kissing disease and cause of infectious mononucleosis. While we know a lot about the heavy fatigue, the lost school days, the swollen tonsils and the body tenderness that can last for days and weeks with. The Epstein-Barr virus can sometimes cause cancer, alongside six other viruses which are presently known to cause cancer in humans, and it is this link to cancer that led to researchers discovering the virus in the first place. After World War II, an Irish surgeon by the name of Denis Parsons Burkitt spent many years in Uganda, where he. Jeong JY, Woo JH, Kim YS, et al. Nuclear factor-kappa B inhibition reduces markedly cell proliferation in Epstein-Barr virus-infected stomach cancer, but affects variably in Epstein-Barr virus-negative stomach cancer. Cancer Investig. 2010;28:113-9. CAS Article Google Scholar 27 Relationship between Epstein-Barr virus and can-cer development Epstein-Barr virus (EBV) is an infectious agent with tropism for lymphoid cells and occasionally for epithelial cells. Twenty years ago it was classified by the International Agency for Research on Cancer (IARC) as type I carcinogen, because during laten

Gastric cancer (GC) is the 4th most common type of cancer worldwide. Different GC subtypes have unique molecular features that may have different therapeutic methods. The aim of the present study was to investigate Epstein-Barr virus (EBV) infection, microsatellite instability (MSI) status, the expression of programmed death-ligand 1 (PD-L1) and gene mutations in GC patients Epstein-Barr virus-associated gastric cancer (EBVaGC) is 10% of all gastric carcinomas, representing the fifth-most common cancer worldwide and the third-most deadly cancer. Gastric cancer is a multifactorial disease that is associated with several risk factors that could contribute to the cause of this disease Epstein-Barr Virus is known to cause illnesses including infectious mononucleosis, Burkitt's lymphoma, Hodgkin's Lymphoma, nasopharyngeal carcinoma, gastric cancer, lymphoma common in transplant patients, and numerous other types of cancer Epstein-Barr Virus may also be the leading cause of autoimmune flares or other conditions linked to EBV. Apart from the patient's symptoms after reactivation of this virus, there might be several medical conditions that develop as the virus stays inside the body, increasing inflammation and possibly even weakening the immune system